Bevacirel 400mg Injection

BEVACIREL 400MG contains Bevacizumab which belongs to a group of medicines called antiangiogenic agents.

It is indicated to treat metastatic colorectal cancer, first-line non-squamous non small cell lung cancer, recurrent glioblastoma (GBM), metastatic renal cell carcinoma, persistent, recurrent, or metastatic cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer and hepatocellular carcinoma.

Bevacizumab is a humanized monoclonal IgG1 antibody which contains human framework regions and murine complementarity determining regions.

This binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells.

This interaction of VEGF with its receptors leads to endothelial cell proliferation and new blood vessel formation in invitro models of angiogenesis. Bevacizumab reduces microvascular growth and inhibition of metastatic disease progression.

Before receiving this BEVACIREL 400MG, tell your physician if you have liver, kidney or heart problems, are pregnant or breastfeeding.

This medicine is not suitable for use in children and adolescents below 18 years of age.
The common side effects are nose or rectal bleeding, headache, back pain or increased blood pressure.

USES OF BEVACIREL 400MG

Treats,

• Metastatic colorectal cancer
• First-line non-squamous non small cell lung cancer
• Recurrent glioblastoma (GBM)
• Metastatic renal cell carcinoma
• Persistent, recurrent, or metastatic cervical cancer
• Epithelial ovarian
• Fallopian tube, or primary peritoneal cancer and
• Hepatocellular carcinoma

HOW BEVACIREL 400MG WORKS

Bevacizumab belongs to antiangiogenic agents which works by stopping the formation of blood vessels that bring oxygen and nutrients to tumors and slows the growth and spread of tumors.

DIRECTIONS FOR USE

BEVACIREL 400MG will be administered as an intravenous infusion by your doctor or nurse.

SIDE EFFECTS OF BEVACIREL 400MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and drink plenty of fluids. Apply a wet or cold cloth to forehead and rest in a quiet, comfortable, dark room.

Back pain:

Use an ice pack or over the counter medicines to relieve pain.

INTERACTIONS

Tell your doctor if you are taking,

• Paclitaxel
• Carboplatin

SYNOPSIS

MORE INFORMATION

• Keep out of reach of children
• Store at 2 – 8°C

FAQs ABOUT BEVACIREL 400MG

Can BEVACIREL 400MG be used during pregnancy?

It is not suitable for use in pregnant women, unless prescribed by your doctor.

How BEVACIREL 400MG works differently from chemotherapy?

It prevents the growth of new blood vessels that feed tumors and causes the tumour to shrink, or to stop growing.

How is BEVACIREL 400MG given?

It will be administered intravenously by your doctor or nurse.

PRODUCT INTRODUCTION

most common side effects

USES OF BEVACIREL INJECTION

• Cancer of colon and rectum
• Non-small cell lung cancer
• Kidney cancer
• Brain tumor
• Ovarian cancer
• Cervical cancer

BENEFITS OF BEVACIREL INJECTION

In Cancer of colon and rectum

Cancer of the colon and rectum, also known as colorectal cancer (CRC) or bowel cancer, is the development of cancer from two parts of the large intestine, namely, the colon or rectum.

In this type of cancer, the person may notice symptoms such as blood in the stool, a change in bowel movements, weight loss, and fatigue.

Bevacirel 400mg Injection treats and also lowers the risk of developing further cancerous growths (polyps) and bowel cancer.

It kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor.

In Non-small cell lung cancer

Non-small cell lung cancer is one of the major kinds of lung cancer and it affects both smokers as well as non-smokers.

Bevacirel 400mg Injection helps treat non-small cell lung cancer and may be given alone or in combination with other medicines.
It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor.

You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

In Kidney cancer

Bevacirel 400mg Injection is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc.
It stops cancer growth and prevents multiplication of cancer cells.

This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

In Brain tumor

Brain tumor is an abnormal mass or collection of cells that may be cancerous (malignant) or non-cancerous (benign).

Bevacirel 400mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. Consult your doctor if you have any doubts.

In Ovarian cancer

Ovarian cancer is a cancer that begins in the female organs that produce eggs (ovaries). This type of cancer is usually detected very late and can be fatal too.

It usually spreads to the pelvis and stomach. Bevacirel 400mg Injection kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells.

It is an effective medicine but has some side effects that may be bothersome.
So, you should discuss the risks and benefits with your doctor.

In Cervical cancer

Bevacirel 400mg Injection is an anti-cancer medicine that is used to kill cancerous cells in cervical cancer, a cancer that develops in the cervix of a female.

The affected female may have symptoms such as abnormal bleeding, foul smelling vaginal discharge, lower back pain, or may even have no symptoms at all.

It has a lot of side effects and you must discuss the risks and benefits with your doctor before starting treatment with this medicine.

SIDE EFFECTS OF BEVACIREL INJECTION

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Bevacirel

• Rectal bleeding
• Taste change
• Headache
• Nosebleeds
• Back pain
• Dry skin
• High blood pressure
• Protein in urine
• Inflammation of the nose

HOW TO USE BEVACIREL INJECTION

Your doctor or nurse will give you this medicine. Kindly do not self administer.

HOW BEVACIREL INJECTION WORKS

Bevacirel 400mg Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.

SAFETY ADVICE

Alcohol

It is not known whether it is safe to consume alcohol with Bevacirel 400mg Injection. Please consult your doctor.

Pregnancy

Bevacirel 400mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

Bevacirel 400mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

Bevacirel 400mg Injection may cause side effects which could affect your ability to drive.
Sleepiness and fainting have been reported with Bevacirel 400mg Injection and this may impair your ability to drive.

Kidney

Bevacirel 400mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Bevacirel 400mg Injection may not be needed in these patients. Please consult your doctor.

Liver

Bevacirel 400mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Bevacirel 400mg Injection may not be needed in these patients. Please consult your doctor.

WHAT IF YOU FORGET TO TAKE BEVACIREL INJECTION?

If you miss a dose of Bevacirel 400mg Injection, please consult your doctor.