MEXATE 5MG contains methotrexate which belong to a group of medicines called folate antagonist. It can be used to treat severe cases of psoriasis and rheumatoid arthritis. It can also be used to treat several kinds of cancer.
Psoriasis is an autoimmune disorder that causes your skin cells to grow and multiply much quickly than normal cells. Methotrexate kills the rapidly multiplying cells in the skin.
In rheumatoid arthritis, methotrexate reduce inflammation in joints by altering body’s defence mechanism in immune system. In cancer, methotrexate inhibits the enzymes responsible for nucleotide synthesis and prevents cell division.
Always take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the dose and duration of the therapy depending upon your health condition.
This medicine should be used with caution in children and in elderly patient. Consult your doctor before taking this medicine. The common side effects are nausea or vomiting, anorexia (eating disorder), a skin rash with reddening of the skin, hair loss.
USES OF MEXATE 5MG:
Treat severe cases of psoriasis and rheumatoid arthritis if other treatments are not effective
Treat several kinds of cancer, including acute leukemias, non-Hodgkin’s lymphoma, soft tissue and bone sarcomas, solid tumors like breast, lung, head and neck, bladder, cervical, ovarian and testicular cancer
HOW MEXATE 5MG WORKS:
Methotrexate inhibits the enzymes responsible for nucleotide synthesis including dihydrofolate reductase, thymidylate synthase, aminoimidazole caboxamide ribonucleotide transformylase (AICART) and amido phosphoribosyl transferase which prevents cell division and leads to anti-inflammatory actions.
Since cellular proliferation in malignant tissues (cancerous tissue) are greater than in most normal tissues, methotrexate may impair malignant growth without causing any irreversible damage to normal tissues. Methotrexate has immunosuppressive effects, and this might be a result of inhibition of lymphocyte multiplication. In psoriasis, it kills the rapidly multiplying skin cells.
DIRECTIONS FOR USE:
Always take MEXATE 5MG as directed by your physician. Your doctor will decide the dose and duration of the therapy depending upon your age, weight and condition. Swallow the medicine as a whole with a glass of water. Do not crush or chew.
SIDE EFFECTS OF MEXATE 5MG:
Nausea or vomiting
Anorexia (eating disorder)
A skin rash with reddening of the skin
A lump in your neck, groin or armpits with associated backache, weight loss or night sweats
Herpes zoster infection
Depression, confusion, loss of interest in, or inability to have sex
Tenderness and swelling of the lower extremities (clot in the veins)
Difficulty in breathing
Swelling of the gums
Abdominal pain, cramping, diarrhoea, dehydration, fever and weight loss
Muscle pain, joint pain
Weakening or softening of bones
Menstrual disorders or impotence
HOW TO MANAGE SIDE EFFECTS:
Nausea or vomiting:
Try taking this medicine with, or just after, a meal. Stick to simple meals.
Drink lots of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
Drug : Methotrexate
Pharmacological Category : Antimetabolite, Antirheumatic, Immunosuppressant Agent
Therapeutic Indication : Psoriasis, Rheumatoid arthritis, Cancer
Dosage Forms : Tablet, Injection, Gel
Store below 20-25°C and keep out of reach of children.
FAQ’s ABOUT MEXATE 5MG:
Q: Will MEXATE 5MG affects fertility?
A: Yes. This medicine may temporarily affect sperm and egg production and cause infertility.
Q: Can MEXATE 5MG be used in pregnant women?
A: No. This medicine is strictly not recommended for use in pregnant women. Consult your doctor before taking.
It is also used to treat severe forms of a skin disease called psoriasis where it works by killing cells in the skin that grow too quickly.
Mexate 5 Tablet may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised.
most common side effects
Your doctor may advise you to take folic acid to reduce some of these. If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects.
Your doctor may perform several tests such as blood tests, x-rays, and physical examinations both before and during treatment with this medicine to check for these.
Before taking it, tell your doctor if you are pregnant, have problems related to the stomach, liver, or kidney, or are taking any medicines to treat infections.
This medicine is not recommended during pregnancy or while breastfeeding as it may harm the baby.
BENEFITS OF MEXATE TABLET
In Treatment of Rheumatoid arthritis
It works by reducing the body’s immune system, this decreases swelling, reduces pain, stiffness, and improves function.
Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.
In Treatment of Psoriasis
Mexate 5 Tablet works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor.
Take it exactly as prescribed and for as long as it is prescribed to get the most benefit.
DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
USES OF MEXATE TABLET
- Treatment of Rheumatoid arthritis
- Treatment of Psoriasis
SIDE EFFECTS OF MEXATE TABLET
Common side effects of Mexate
- Abdominal pain
- Loss of appetite
- Mouth sore
HOW TO USE MEXATE TABLET
HOW MEXATE TABLET WORKS
Regular monitoring of kidney function test is advised while you are taking this medicine.
Use of Mexate 5 Tablet is not recommended in patients with severe liver disease.