Mexate 5 mg Tablet

MEXATE 5MG contains methotrexate which belong to a group of medicines called folate antagonist. It can be used to treat severe cases of psoriasis and rheumatoid arthritis. It can also be used to treat several kinds of cancer.

Psoriasis is an autoimmune disorder that causes your skin cells to grow and multiply much quickly than normal cells. Methotrexate kills the rapidly multiplying cells in the skin.

In rheumatoid arthritis, methotrexate reduce inflammation in joints by altering body’s defence mechanism in immune system. In cancer, methotrexate inhibits the enzymes responsible for nucleotide synthesis and prevents cell division.

Always take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the dose and duration of the therapy depending upon your health condition.

This medicine should be used with caution in children and in elderly patient. Consult your doctor before taking this medicine. The common side effects are nausea or vomiting, anorexia (eating disorder), a skin rash with reddening of the skin, hair loss.

USES OF MEXATE 5MG:

Treat severe cases of psoriasis and rheumatoid arthritis if other treatments are not effective
Treat several kinds of cancer, including acute leukemias, non-Hodgkin’s lymphoma, soft tissue and bone sarcomas, solid tumors like breast, lung, head and neck, bladder, cervical, ovarian and testicular cancer

HOW MEXATE 5MG WORKS:

Methotrexate inhibits the enzymes responsible for nucleotide synthesis including dihydrofolate reductase, thymidylate synthase, aminoimidazole caboxamide ribonucleotide transformylase (AICART) and amido phosphoribosyl transferase which prevents cell division and leads to anti-inflammatory actions.

Since cellular proliferation in malignant tissues (cancerous tissue) are greater than in most normal tissues, methotrexate may impair malignant growth without causing any irreversible damage to normal tissues. Methotrexate has immunosuppressive effects, and this might be a result of inhibition of lymphocyte multiplication. In psoriasis, it kills the rapidly multiplying skin cells.

DIRECTIONS FOR USE:

Always take MEXATE 5MG as directed by your physician. Your doctor will decide the dose and duration of the therapy depending upon your age, weight and condition. Swallow the medicine as a whole with a glass of water. Do not crush or chew.

SIDE EFFECTS OF MEXATE 5MG:

COMMON

Nausea or vomiting
Anorexia (eating disorder)
A skin rash with reddening of the skin
Hair loss
A lump in your neck, groin or armpits with associated backache, weight loss or night sweats
Nosebleed
Vaginal ulcers

RARE

Herpes zoster infection
Depression, confusion, loss of interest in, or inability to have sex
Tenderness and swelling of the lower extremities (clot in the veins)
Difficulty in breathing
Throat infection
Swelling of the gums
Abdominal pain, cramping, diarrhoea, dehydration, fever and weight loss
Muscle pain, joint pain
Weakening or softening of bones
Menstrual disorders or impotence

HOW TO MANAGE SIDE EFFECTS:

Nausea or vomiting:

Try taking this medicine with, or just after, a meal. Stick to simple meals.

Diarrhea:

Drink lots of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

SYNOPSIS:

Drug : Methotrexate
Pharmacological Category : Antimetabolite, Antirheumatic, Immunosuppressant Agent
Therapeutic Indication : Psoriasis, Rheumatoid arthritis, Cancer
Dosage Forms : Tablet, Injection, Gel

MORE INFORMATION:

Store below 20-25°C and keep out of reach of children.

FAQ’s ABOUT MEXATE 5MG:

Q: Will MEXATE 5MG affects fertility?
A: Yes. This medicine may temporarily affect sperm and egg production and cause infertility.

Q: Can MEXATE 5MG be used in pregnant women?
A: No. This medicine is strictly not recommended for use in pregnant women. Consult your doctor before taking.

PRODUCT INTRODUCTION

Mexate 5 Tablet is a medicine used to treat rheumatoid arthritis where it helps prevent further joint damage.
It is also used to treat severe forms of a skin disease called psoriasis where it works by killing cells in the skin that grow too quickly.

Mexate 5 Tablet may be used alone or in combination with other medicines. You should take it exactly as your doctor has advised.

most common side effects

USES OF MEXATE TABLET

• Treatment of Rheumatoid arthritis
• Treatment of Psoriasis

SIDE EFFECTS OF MEXATE TABLET

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Mexate

• Abdominal pain
• Indigestion
• Loss of appetite
• Nausea
• Vomiting
• Tiredness
• Mouth sore

HOW TO USE MEXATE TABLET

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mexate 5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

HOW MEXATE TABLET WORKS

Mexate 5 Tablet is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body’s immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid growth of skin cells.

SAFETY ADVICE

Alcohol

Caution is advised when consuming alcohol with Mexate 5 Tablet. Please consult your doctor.

Pregnancy

Mexate 5 Tablet is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

Mexate 5 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

Mexate 5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

Mexate 5 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Mexate 5 Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.

Liver

Mexate 5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Mexate 5 Tablet may be needed. Please consult your doctor.
Use of Mexate 5 Tablet is not recommended in patients with severe liver disease.

WHAT IF YOU FORGET TO TAKE MEXATE TABLET?

If you miss a dose of Mexate 5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.