Votrient 200 mg Tablet

VOTRIENT 200MG contains pazopanib which belongs to the group of medicines called tyrosine kinase inhibitors. It is used to treat advanced kidney cancer or certain forms of soft-tissue sarcoma (a type of cancer that affects the supportive tissues of the body) in adults.

It prevents the activity of proteins which are involved in the growth and spread of cancer cells. It can raise your blood pressure.
So, inform your doctor if you are previously suffering from high blood pressure.

Try taking this medicine at the same time each day.
Take it at least 1 hour before or 2 hours after a meal. Avoid drinking grapefruit juice while taking this medicine.

Take VOTRIENT 200MG as directed by your physician. Do not take this medicine with food. Take it at least 1 hour before or 2 hours after a meal. Before taking this medicine, inform your doctor if you are undergoing any operation.

This medicine may affect fertility in both men and women and should not be used in pregnant or breastfeeding women and in children below 18 years of age.

Do not drive or operate any machines if you feel dizzy, tired or weak, or if your energy levels are low.

The common side effects such as diarrhea, nausea, vomiting, bloating, stomach pain, loss of appetite, weight loss, taste disturbance, sore mouth and headache.

USES OF VOTRIENT 200MG:

Treats advanced kidney cancer or advanced soft-tissue sarcoma in adults

HOW VOTRIENT 200MG WORKS:

VOTRIENT 200MG is a tyrosine kinase inhibitor which inhibits the activity of various growth factor receptors associated with angiogenesis and tumor cell proliferation.

Following oral administration, it inhibits the activity of vascular endothelial growth factor receptor-1, -2 and -3, platelet-derived growth factor receptor-alpha and -beta and c-kit and prevents the growth and spread of cancer cells.

DIRECTIONS FOR USE:

Take VOTRIENT 200MG as directed by your physician. Do not take this medicine with food. Take it at least 1 hour before or 2 hours after a meal.

Try taking this medicine at the same time each day. Avoid drinking grapefruit juice while taking this medicine, which may increase the chance of side effects.

Your doctor will decide the correct dose for you depending upon your condition. Do not stop taking this medicine, unless your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF VOTRIENT 200MG:

SERIOUS

Reversible posterior leukoencephalopathy syndrome (such as swelling of the brain with loss of speech, change of vision, seizure, confusion and high blood pressure)
Cardiovascular dysfunction (such as irregular heartbeat, fainting, chest pain, pain in arms, back, neck or jaw, shortness of breath, leg swelling and stroke)
Passing blood in stools or urine
Yellowing of skin or whites of eyes
Dark urine
Tumor lysis syndrome
Infections (such as fever, flu-like symptoms)

COMMON

High blood pressure
Diarrhea, nausea, vomiting, bloating, stomach pain, loss of appetite
Weight loss
Taste disturbance
Sore mouth
Headache
Tumor pain
Feeling weak or tired
Unusual hair loss or thinning
Loss of skin pigment, skin rash, redness and swelling of palms or soles
Slow heartbeat
Swelling of face, hands, ankles, feet or eyelids
Tingling, weakness or numbness of hands, arms, legs or feet
Unusual bleeding
Sensation of coldness and shivering
Excessive sweating
Dehydration
Muscle, joint or tendon pain
  Coughing up blood

RARE

Pneumonitis (inflammation of lung)

HOW TO MANAGE SIDE EFFECTS:

Nausea or vomiting:

Try taking this medicine with or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Bloating:

Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor immediately.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

INTERACTIONS:

Talk to your doctor, if you are taking,

Medicines used to treat bacterial infection (e.g. clarithromycin, ketoconazole, itraconazole, rifampicin, telithromycin, voriconazole)
Medicines used to treat HIV infections (e.g. atazanavir, indinavir, nelfinavir, ritonavir, saquinavir)
Medicines used to reduce stomach acid (e.g. omeprazole, cimetidine, ranitidine, aluminium hydroxide)
Nefazodone (used to treat depression)
Statins (used to treat high cholesterol levels) e.g. simvastatin, atorvastatin, rosuvastatin

SYNOPSIS:

Drug : Pazopanib
Pharmacological Category :
Anti-neoplastic agent, Tyrosine kinase inhibitor vascular endothelial growth factor receptor inhibitor

Therapeutic Indication : Advanced kidney cancer, Advanced soft-tissue sarcoma
Dosage Forms : Tablet

MORE INFORMATION:

Store below 20-25°C and keep out of reach of children.

FAQ’s ABOUT VOTRIENT 200MG:

Q: Can VOTRIENT 200MG cure cancer?
A: Yes. This medicine is used to cure advanced kidney cancer or soft-tissue sarcoma in adults.

Q: Can VOTRIENT 200MG be taken with simvastatin?
A: No. Avoid concomitant use of simvastatin with this medicine, because it may increase the risk of side effects.

Q: Can VOTRIENT 200MG be used in children?
A: No. This medicine is strictly not recommended for use in children below 18 years of age.

PRODUCT INTRODUCTION

Votrient 200mg Tablet is a protein kinase inhibitor used in the treatment of kidney cancer and soft tissue sarcoma.

Votrient 200 mg Tablet should be taken on an empty stomach, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it.

This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. click here : Votrient 200 

most common side effects

SIDE EFFECTS OF VOTRIENT TABLET

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Votrient

• Headache
• Nausea
• Vomiting
• Musculoskeletal (bone, muscle or joint) pain
• Fatigue
• Change in color of hair
• Diarrhea
• High blood pressure
• Decreased appetite
• Weight loss
• Taste change
• Abnormal skin pigmentation
• Hair discoloration
• Tumor pain
• Breathlessness

HOW TO USE VOTRIENT TABLET

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
Votrient 200mg Tablet is to be taken empty stomach.

HOW VOTRIENT TABLET WORKS

Votrient 200mg Tablet is an anti-cancer medication. It works by binding and inhibiting the enzyme receptors (tyrosine kinase) that are responsible for the proliferation of the cancerous cells.
It also restricts the growth of new blood vessels within the tumor. This is how it works against cancer.

SAFETY ADVICE

Alcohol

It is not known whether it is safe to consume alcohol with Votrient 200mg Tablet. Please consult your doctor.

Pregnancy

Votrient 200mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

Votrient 200mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

Votrient 200mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

Votrient 200mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Votrient 200mg Tablet is recommended.

Liver

Votrient 200mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Votrient 200mg Tablet may be needed. Please consult your doctor.
Use of Votrient 200mg Tablet is not advised in patients with moderate to severe liver disease.

FAQs

Q. Is Votrient 200mg Tablet a chemotherapy medicine?

Votrient 200mg Tablet is not a conventional chemotherapy medicine. It belongs to a class of medicine called a protein kinase inhibitor. Votrient 200mg Tablet works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.

Q. How should I take Votrient 200mg Tablet?

Votrient 200mg Tablet should be taken orally by mouth once a day or as directed by your doctor. Swallow the tablets whole with water, do not break or crush the tablets. This affects the way the medicine is absorbed and may increase the chance of side effects.

Q. Can Votrient 200mg Tablet be taken with food?

Votrient 200mg Tablet should be taken on an empty stomach, at least 1 hour before or 2 hours after food. If it is taken with food, the dosage may need to be increased. Doing this will in turn cause more side effects.