HERDUO 250 mg Tablet

HERDUO 250MG contains Lapatinib which belongs to the group of medicines called antineoplastic agent.
It is used to treat HER2-positive breast cancer which have spread beyond the original tumor or to other organs (advanced or metastatic breast cancer).

HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2), which is capable of promoting the growth of cancer cells.

Lapatinib is generally prescribed with other anti-cancer medicine like capecitabine, trastuzumab (for patients with hormone receptor-negative metastatic breast cancer) or aromatase inhibitor (for patients with hormone sensitive metastatic breast cancer). It slows or stops cancer cells from growing or may kill them.

Always take this medicine as directed by your physician. Take this medicine, either at least 1 hour before or 1 hour after food. Prior to the treatment, your doctor will check whether your heart and lungs are working properly or not.

Avoid consumption of alcohol while taking this medicine. Do not drive or operate any machines if your ability is affected by this medicine. Talk to your doctor immediately at the first sign of diarrhea, because it is important that this is treated right away.

Do not take this medicine, if you have diarrhea, liver, kidney or lung problems or are pregnant. The most common side effect of taking this medicine is diarrhea, rash, dry skin, itching, loss of appetite, stomach pain, indigestion, constipation, nausea or vomiting, tiredness, mouth ulcers, trouble in sleeping, pain in hands and feet.

USES OF HERDUO 250MG:

HER2-positive metastatic breast cancer

HOW HERDUO 250MG WORKS:

HERDUO 250MG is an inhibitor of intracellular tyrosine kinase domains of both HER2 and epidermal growth factor receptor (EGFR). It passes through the cell membrane and binds to HER2 and EGFR, found inside the cell. Inhibition of HER2 and EGFR receptors by lapatinib, inhibits the HER2-derived tumor cell growth and division, which in turn reduces tumor cell proliferation.

DIRECTIONS FOR USE:

Always take this medicine as directed by your physician. Take this medicine, either at least 1 hour before or 1 hour after food. Your doctor will decide the correct dose for you depending upon your condition. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results. Do not drink grapefruit juice while you are taking HERDUO 250MG.

SIDE EFFECTS OF HERDUO 250MG:

SERIOUS

Diarrhea

COMMON

Rash, dry skin, itching
Loss of appetite, stomach pain, indigestion, constipation
Nausea or vomiting
Tiredness
Mouth ulcers
Trouble in sleeping
Pain in hands and feet
Joint or back pain
Skin reaction on palms of hands or soles of feet (including tingling, numbness, pain, swelling or reddening)
Cough, shortness of breath
Headache
Nose-bleed
Hot flush
Unusual hair loss or thinning
Jaundice (yellow eyes or skin)
Dark urine
Nail infection

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after a meal or a snack. Stick to simple meals. Do not eat rich or spicy food.

Constipation:

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

SYNOPSIS

Drug : Lapatinib
Pharmacological Category : Antineoplastic Agent, HER2-inhibitor, EGFR inhibitor, Tyrosine Kinase Inhibitor
Therapeutic Indication :
HER2-positive metastatic breast cancer

Dosage Forms : Tablet

MORE INFORMATION

Store below 20-25?C and keep out of reach of children.

FAQs ABOUT HERDUO 250MG:

Q: What is the most common side effect of HERDUO 250MG?
A: The most common side effect of this medicine is diarrhoea. Drink lots of fluids, such as water or juice, to avoid dehydration. Consult your doctor immediately if it is severe.

Q: Will HERDUO 250MG cause hair loss?
A: Yes. This medicine may cause unusual hair thinning or loss. Consult your doctor for advice.

Q: Can we take HERDUO 250MG with juice?
A: No. Take this tablet only with water. Avoid drinking juices while taking this medicine, especially grapefruit juice, as it may lead to serious interactions.

SAFETY ADVICE

Alcohol

It is not known whether it is safe to consume alcohol with Herduo Tablet. Please consult your doctor.

Pregnancy

Herduo Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

Herduo 250 mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

Herduo 250 mg Tablet may cause side effects which could affect your ability to drive.

Kidney

Herduo 250 mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Herduo 250 mg Tablet may be needed. Please consult your doctor.
Limited information is available on the use of Herduo Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.

Liver

Herduo 250 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Herduo Tablet may be needed. Please consult your doctor.
Limited information is available on the use of this medicine in patients with the severe liver disease.