Mexate 2.5 mg Tablet

MEXAT 2.5MG contains methotrexate which belong to a group of medicines called folate antagonist.

It can be used to treat severe cases of psoriasis and rheumatoid arthritis.

It can also be used to treat several kinds of cancer.
Psoriasis is an autoimmune disorder that causes your skin cells to grow and multiply much quickly than normal cells.

Methotrexate kills the rapidly multiplying cells in the skin. In rheumatoid arthritis, methotrexate reduce inflammation in joints by altering body’s defence mechanism in immune system. In cancer, methotrexate inhibits the enzymes responsible for nucleotide synthesis and prevents cell division.

Always take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the dose and duration of the therapy depending upon your health condition. This medicine should be used with caution in children and in elderly patient.

Consult your doctor before taking this medicine. The common side effects are nausea or vomiting, anorexia (eating disorder), a skin rash with reddening of the skin, hair loss.

USES OF MEXAT 2.5MG:

Treat severe cases of psoriasis and rheumatoid arthritis if other treatments are not effective
Treat several kinds of cancer, including acute leukemias, non-Hodgkin’s lymphoma, soft tissue and bone sarcomas, solid tumors like breast, lung, head and neck, bladder, cervical, ovarian and testicular cancer

HOW MEXAT 2.5MG WORKS:

Methotrexate inhibits the enzymes responsible for nucleotide synthesis including dihydrofolate reductase, thymidylate synthase, aminoimidazole caboxamide ribonucleotide transformylase (AICART) and amido phosphoribosyl transferase which prevents cell division and leads to anti-inflammatory actions.

Since cellular proliferation in malignant tissues (cancerous tissue) are greater than in most normal tissues, methotrexate may impair malignant growth without causing any irreversible damage to normal tissues.

Methotrexate has immunosuppressive effects, and this might be a result of inhibition of lymphocyte multiplication.
In psoriasis, it kills the rapidly multiplying skin cells.

DIRECTIONS FOR USE:

Always take MEXAT 2.5MG as directed by your physician.

Your doctor will decide the dose and duration of the therapy depending upon your age, weight and condition.
Swallow the medicine as a whole with a glass of water. Do not crush or chew.

SIDE EFFECTS OF MEXAT 2.5MG:

COMMON

Nausea or vomiting
Anorexia (eating disorder)
A skin rash with reddening of the skin
Hair loss
A lump in your neck, groin or armpits with associated backache, weight loss or night sweats
Nosebleed
Vaginal ulcers

RARE

Herpes zoster infection
Depression, confusion, loss of interest in, or inability to have sex
Tenderness and swelling of the lower extremities (clot in the veins)
Difficulty in breathing
Throat infection
Swelling of the gums
Abdominal pain, cramping, diarrhoea, dehydration, fever and weight loss
Muscle pain, joint pain
Weakening or softening of bones
Menstrual disorders or impotence

HOW TO MANAGE SIDE EFFECTS:

Nausea or vomiting:

Try taking this medicine with, or just after, a meal. Stick to simple meals.

Diarrhea:

Drink lots of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

SYNOPSIS:

Drug : Methotrexate
Pharmacological Category : Antimetabolite, Antirheumatic, Immunosuppressant Agent
Therapeutic Indication : Psoriasis, Rheumatoid arthritis, Cancer
Dosage Forms : Tablet, Injection, Gel

MORE INFORMATION:

Store below 20-25°C and keep out of reach of children.

FAQ’s ABOUT MEXAT 2.5MG:

Q: Will MEXAT 2.5MG affects fertility?
A: Yes. This medicine may temporarily affect sperm and egg production and cause infertility.

Q: Can MEXAT 2.5MG be used in pregnant women?
A: No. This medicine is strictly not recommended for use in pregnant women. Consult your doctor before taking.

USES OF MEXATE TABLET

• Treatment of Rheumatoid arthritis
• Treatment of Psoriasis

BENEFITS OF MEXATE TABLET

In Treatment of Rheumatoid arthritis

Mexate 2.5 Tablet belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked.

It is not a first-line treatment. It works by reducing the body’s immune system, this decreases swelling, reduces pain, stiffness, and improves function.

Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.

In Treatment of Psoriasis

Mexate 2.5 Tablet belongs to a group of medicines called antimetabolites. It may be used to treat severe psoriasis when other treatments have not worked.
Psoriasis is a condition where the skin cells in the body grow too quickly.

Mexate 2.5 Tablet works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor.
Take it exactly as prescribed and for as long as it is prescribed to get the most benefit.

DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

SIDE EFFECTS OF MEXATE TABLET

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Mexate

• Abdominal pain
• Indigestion
• Loss of appetite
• Nausea
• Vomiting
• Tiredness
• Mouth sore

HOW TO USE MEXATE TABLET

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.

Mexate 2.5 Tablet may be taken with or without food, but it is better to take it at a fixed time.

HOW MEXATE TABLET WORKS

Mexate 2.5 Tablet is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body’s immune system.

This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid growth of skin cells.

SAFETY ADVICE

Alcohol

Caution is advised when consuming alcohol with Mexate 2.5 Tablet. Please consult your doctor.

Pregnancy

Mexate 2.5 Tablet is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

Mexate 2.5 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

Mexate 2.5 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

Mexate 2.5 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Mexate 2.5 Tablet may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.

Liver

Mexate 2.5 Tablet should be used with caution in patients with liver disease. Dose adjustment of Mexate 2.5 Tablet may be needed. Please consult your doctor.
Use of Mexate 2.5 Tablet is not recommended in patients with severe liver disease.

WHAT IF YOU FORGET TO TAKE MEXATE TABLET?

If you miss a dose of Mexate 2.5 Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.