Myelostat 500 mg Capsule

MYELOSTAT 500MG contains Hydroxyurea which belongs to the group of medicines called antineoplastic agents.
It is indicated for the treatment of resistant chronic myelocytic leukemia (blood cell cancer), ovarian cancer and skin cancer (melanoma).
It can also be used to treat locally advanced squamous cell carcinomas of head and neck in combination with chemoradiation.

Inside the cells, hydroxyurea causes an immediate inhibition of DNA synthesis by inhibiting the enzyme ribonucleotide reductase and produces cell death in S phase.
Your doctor will decide the correct dose for you depending upon your condition.
Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

most common side effects

The most common side effects are nausea, vomiting, loss of appetite and constipation. Hydroxyurea may harm an unborn baby.
Both women and men using this medicine should use birth control to prevent pregnancy, because the use of this medicine by either parent may cause birth defects.
Before taking this medicine, inform your doctor if you have any marked bone marrow depression, severe anemia, liver or kidney disease.

USES OF MYELOSTAT 500MG:

Resistant chronic myelocytic leukemia
Ovarian cancer
Melanoma (skin cancer)
Locally advanced squamous cell carcinomas of head and neck

HOW MYELOSTAT 500MG WORKS:

Following oral administration, hydroxyurea is converted to free radical nitroxide (NO) and enters into the cells, which inactivates the enzyme ribonucleotide reductase.
Inactivation of this enzyme causes an immediate inhibition of DNA synthesis and produces cell death in S phase.

DIRECTIONS FOR USE:

Take MYELOSTAT 500MG as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF MYELOSTAT 500MG:

SERIOUS

Numbness, tingling, or burning pain in your hands or feet
Skin numbness or purple discoloration
Skin ulcers or open sores
Sudden chest pain and wheezing
Upper stomach pain
Fast heart rate
Dark urine
Jaundice (yellowing of the skin or eyes)

COMMON

Loss of appetite
Nausea or vomiting
Constipation, diarrhea
Low blood cell counts
Bleeding
Mouth sores

HOW TO MANAGE SIDE EFFECTS:

Nausea or vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Constipation:

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

INTERACTIONS:

Talk to your doctor, if you are taking,

Other myelosuppressive agents (anti-cancer medicines) e.g. peginterferon alpga-2A, rituximab, alentuzumab
Live viral vaccine (varicella vaccine, MMR vaccine)
Antiretroviral Drugs (used to treat HIV) e.g. abacavir, didanosine, zidovudine

SYNOPSIS:

Drug : Hydroxyurea
Pharmacological Category : Anti-neoplastic agent
Therapeutic Indication : Resistant chronic myelocytic leukemia, Ovarian cancer, Melanoma, squamous cell carcinomas of head and neck
Dosage Forms : Capsule

MORE INFORMATION:

Store below 20-25°C and keep out of reach of children.

FAQ’s ABOUT MYELOSTAT 500MG:

Q: Can MYELOSTAT 500MG cause liver damage?
A: Yes. It may cause liver damage in some individuals. Check with your doctor.

Q: Can MYELOSTAT 500MG be used during pregnancy?
A: No. It may harm an unborn baby. It is not recommended for use in pregnancy.

PRODUCT INTRODUCTION

Most common side effects

USES OF MYELOSTAT CAPSULE

• Head and neck cancer
• Sickle cell anemia

BENEFITS OF MYELOSTAT CAPSULE

In Head and neck cancer

Head and neck cancer includes cancer of the mouth, nose, sinuses or throat. Myelostat 500mg Capsule kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

In Sickle cell anemia

Sickle cell anemia is a disorder of the red blood cells (RBCs) in which they lose their original round shape and flexibility, turn sickle shape and eventually die out. Myelostat 500mg Capsule makes your red blood cells bigger. It helps them stay rounder and more flexible and makes them less likely to turn into a sickle shape. The medicine does this by increasing a special kind of hemoglobin called hemoglobin F. Hemoglobin F is also called fetal hemoglobin because newborn babies have it. This helps to treat this disease and also prevents further complications that may be life-threatening.

SIDE EFFECTS OF MYELOSTAT CAPSULE

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Myelostat

• Hematological disorder
• Gastrointestinal disorder
• Eating disorder
• Loss of appetite

HOW TO USE MYELOSTAT CAPSULE

Take this medicine in the dose and duration as advised by your doctor. Myelostat 500mg Capsule may be taken with or without food, but it is better to take it at a fixed time.

HOW MYELOSTAT CAPSULE WORKS

In cancer, Myelostat 500mg Capsule works by blocking an enzyme (ribonucleotide reductase) which is required for synthesis of DNA. This prevents the cancer cells from growing and multiplying. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) levels in red blood cells (RBCs). This helps the RBCs assume a normal shape, improves blood flow and protects against complications such as painful sickle cell episodes.

SAFETY ADVICE

Alcohol

It is not known whether it is safe to consume alcohol with Myelostat 500mg Capsule. Please consult your doctor.

Pregnancy

Myelostat 500mg Capsule is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

Myelostat 500mg Capsule is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

Myelostat 500mg Capsule may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

Myelostat 500mg Capsule should be used with caution in patients with kidney disease. Dose adjustment of Myelostat 500mg Capsule may be needed. Please consult your doctor.
Regular monitoring of kidney function test and some blood tests may be advised while you are taking this medicine.

Liver

Myelostat 500mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Myelostat 500mg Capsule may be needed. Please consult your doctor.