TYKERB 250MG contains Lapatinib which belongs to the group of medicines called antineoplastic agent. It is used to treat HER2-positive breast cancer which have spread beyond the original tumor or to other organs (advanced or metastatic breast cancer).
HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2), which is capable of promoting the growth of cancer cells.
Lapatinib is generally prescribed with other anti-cancer medicine like capecitabine, trastuzumab (for patients with hormone receptor-negative metastatic breast cancer) or aromatase inhibitor (for patients with hormone sensitive metastatic breast cancer).
It slows or stops cancer cells from growing or may kill them.
Always take this medicine as directed by your physician. Take this medicine, either at least 1 hour before or 1 hour after food.
Prior to the treatment, your doctor will check whether your heart and lungs are working properly or not.
Avoid consumption of alcohol while taking this medicine. Do not drive or operate any machines if your ability is affected by this medicine.
Talk to your doctor immediately at the first sign of diarrhea, because it is important that this is treated right away. Do not take this medicine, if you have diarrhea, liver, kidney or lung problems or are pregnant.
The most common side effect of taking this medicine is diarrhea, rash, dry skin, itching, loss of appetite, stomach pain, indigestion, constipation, nausea or vomiting, tiredness, mouth ulcers, trouble in sleeping, pain in hands and feet.
USES OF TYKERB 250MG:
HER2-positive metastatic breast cancer
HOW TYKERB 250MG WORKS:
TYKERB 250MG is an inhibitor of intracellular tyrosine kinase domains of both HER2 and epidermal growth factor receptor (EGFR).
It passes through the cell membrane and binds to HER2 and EGFR, found inside the cell. Inhibition of HER2 and EGFR receptors by lapatinib, inhibits the HER2-derived tumor cell growth and division, which in turn reduces tumor cell proliferation.
DIRECTIONS FOR USE:
Always take this medicine as directed by your physician. Take this medicine, either at least 1 hour before or 1 hour after food.
Your doctor will decide the correct dose for you depending upon your condition. Swallow the medicine as a whole with a glass of water.
Do not crush or chew the medicine. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results. Do not drink grapefruit juice while you are taking TYKERB 250MG.
SIDE EFFECTS OF TYKERB 250MG:
SERIOUS
Diarrhea
COMMON
Rash, dry skin, itching
Loss of appetite, stomach pain, indigestion, constipation
Nausea or vomiting
Tiredness
Mouth ulcers
Trouble in sleeping
Pain in hands and feet
Joint or back pain
Skin reaction on palms of hands or soles of feet (including tingling, numbness, pain, swelling or reddening)
Cough, shortness of breath
Headache
Nose-bleed
Hot flush
Unusual hair loss or thinning
Jaundice (yellow eyes or skin)
Dark urine
Nail infection
HOW TO MANAGE SIDE EFFECTS:
Nausea or vomiting:
Try taking this medicine with, or just after a meal or a snack. Stick to simple meals. Do not eat rich or spicy food.
Constipation:
Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.
Diarrhea:
Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
INTERACTIONS:
Talk to your doctor, if you are taking,
Medicine used to treat depression (nefazodone, St John?s Wort)
Medicines used to treat infections (e.g. erythromycin, ketoconazole, itraconazole, posaconazole, voriconazole, rifabutin, rifampicin, telithromycin)
Medicines used to treat HIV (e.g. ritonavir, saquinavir)
Medicines used to treat seizures (e.g. phenytoin, carbamazepine)
Medicines used to treat heart problems (e.g. quinidine, digoxin)
Medicines used to treat certain types of cancer (e.g. topotecan, paclitaxel, irinotecan, docetaxel)
Medicines that decrease stomach acidity (e.g. aluminium hydroxide)
Cyclosporine (used to suppress the immune system)
Cisapride (used to treat digestive system problems)
Pimozide (used to treat mental health problems)
Repaglinide (used to treat diabetes)
Verapamil (used to treat high blood pressure or angina)
Rosuvastatin (used to treat high cholesterol levels)
SYNOPSIS:
Drug : Lapatinib
Pharmacological Category : Antineoplastic Agent, HER2-inhibitor, EGFR inhibitor, Tyrosine Kinase Inhibitor
Therapeutic Indication :
HER2-positive metastatic breast cancer
Dosage Forms : Tablet
MORE INFORMATION:
Store below 20-25°C and keep out of reach of children.
PRODUCT INTRODUCTION
Tykerb 250mg Tablet should be taken on an empty stomach or an hour before or 2 hours after a meal.
The dose and duration vary according to the severity of your condition and your response to treatment. Take it exactly as prescribed to avoid serious side effects.
It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. click here : Tykerb 250
most common side effects
Before taking Tykerb 250mg Tablet, let your doctor know if you have liver or kidney problems. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are taking. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
USES OF TYKERB TABLET
- Breast cancer
BENEFITS OF TYKERB TABLET
In Breast cancer
SIDE EFFECTS OF TYKERB TABLET
Common side effects of Tykerb
- Abdominal pain
- Back pain
- Breathing problems
- Constipation
- Cough
- Diarrhea
- Fatigue
- Headache
- Hot flashes
- Increased bilirubin in the blood
- Insomnia (difficulty in sleeping)
- Joint pain
- Liver damage
- Loss of appetite
- Mucosal inflammation
- Nausea
- Pain in extremities
- Rash
- Stomatitis (Inflammation of the mouth)
- Vomiting
- Weakness
- Weight gain
HOW TO USE TYKERB TABLET
HOW TYKERB TABLET WORKS
SAFETY ADVICE
Alcohol
Pregnancy
Breast feeding
Driving
Kidney
Limited information is available on the use of Tykerb 250mg Tablet in these patients. No dose adjustment is recommended in patients with mild to moderate kidney disease.
Liver
Limited information is available on the use of this medicine in patients with the severe liver disease.
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